3-[(2,7-Dimethoxyacridin-9-yl)thio]propan-1-amine dihydrochloride

Name	3-(2,7-dimethoxyacridin-9-ylthio)propan-1-amine
Synonyms	CS-613 LDN-192960 LDN-192960 2HCl LDN-192960 dihydrochloride 2,7-Dimethoxy-9-(3'-aminopropyl)thioacridine 3-(2,7-dimethoxyacridin-9-ylthio)propan-1-amine 1-Propanamine, 3-[(2,7-dimethoxy-9-acridinyl)thio]- LDN-192960 3-(2,7-diMethoxyacridin-9-ylthio)propan-1-aMine 3-[(2,7-Dimethoxy-9-acridinyl)thio]-1-propanamine dihydrochloride 3-[(2,7-Dimethoxyacridin-9-yl)thio]propan-1-amine dihydrochloride
CAS	184582-62-5

Molecular Formula	C18H20N2O2S
Molar Mass	328.43
Density	1.25±0.1 g/cm3(Predicted)
Boling Point	536.1±40.0 °C(Predicted)
Solubility	DMSO: soluble20mg/mL, clear
Appearance	powder
Color	white to light brown
pKa	9.33±0.10(Predicted)
Storage Condition	2-8°C
In vitro study	LDN-192960 (10 μM) is selective and inhibits ten of the other kinases by ≥90%, with only five being potently inhibited (IC 50 <1 μM), including CLK1 (IC 50 =0.21 μM), DYRK1A (IC 50 = 0.10 μM), DYRK2 (IC 50 =2 nM), DYRK3 (IC 50 =19 nM) and PIM1 (IC 50 =0.72 μM).LDN-0192960 (0-5 μM; 2 hours) demonstrates that the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells overexpressing Haspin with an EC 50 of 1.17 μM.LDN-0192960 (0-1 μM; 1 hour incubation in the presence of nocodazole and MG132) demonstrates the classical Haspin inhibition phenotype by reducing levels of p-Thr3H3 in HeLa cells synchronized in mitosis with an EC 50 of 0.02 μM.

Hazard Symbols	Xi - Irritant
Risk Codes	36/37/38 - Irritating to eyes, respiratory system and skin.
Safety Description	26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
WGK Germany	3

Last Update：2024-01-02 23:10:35

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